By Xueji Zhang,Haifeng Dong,Yaping Tian
This booklet summarizes microRNA (miRNA) biology in quite a few pathological strategies, emphasizing the numerous power purposes of miRNA in diagnostics and prognostics, in addition to novel drug goals. the traditional suggestions used for miRNA detection together with common PCR, Northern blotting, microarray and clone tools are addressed. contemporary rising ideas in miRNA detection and quantification with better flexibility and suppleness, similar to novel molecular organic strategies and locked nucleic acid (LNA) converted probes, in addition to nanotechnology-based methods, also are integrated. The publication additionally highlights the newest advances in clinical-related miRNA detection tools in residing cells, circulating blood and tissue, resembling in situ hybridization (ISH) and molecular imaging ideas, that are precious to clarify the biogenesis and organic functionality of miRNAs in vivo. eventually, the respective merits and disadvantages of varied detection strategies during this fast-moving box are mentioned, besides the demanding situations and promising new directions.
This publication deals a priceless source for analytical chemists, biologists and physicians interested in miRNA research.
Dr. Xueji Zhang and Dr. Haifeng Dong are Professors on the institution of Chemistry & organic Engineering, college of technology & know-how Beijing (USTB), China.
Dr. Yaping Tian is a Professor on the division of scientific Biochemistry, chinese language PLA common clinic and army scientific university, China.
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MicroRNA Detection and Pathological Functions (SpringerBriefs in Molecular Science) by Xueji Zhang,Haifeng Dong,Yaping Tian